Coronary Angioplasty using a Low Osmolar Nonionic Contrast Medium

Renal failure in 57 925 patients undergoing coronary procedures using iso-osmolar or low-osmolar contrast media.

We compared the Swedish Coronary Angiography and Angioplasty Registry with the Swedish 'Hospital Discharge Register' to assess contrast media (CM)-induced renal failure. Hospitals used only one type CM. From 2000 to 2003, iodixanol (iso-osmolar) was used in 45 485 patients, ioxaglate (low osmolar) in 12 440 subjects. To include the earlier used CM iohexol (low osmolar), analysis extended back t...

Iso-Osmolar versus Low-Osmolar Contrast Media in Reducing Contrast Induced Nephropathy in Patient with Renal Impairment Undergoing Coronary Angiography

Interventional Cardiology A Randomized Trial Comparing the Impact of a Nonionic (Iomeprol) Versus an Ionic (Ioxaglate) Low Osmolar Contrast Medium on Abrupt Vessel Closure and Ischemic Complications After Coronary Angioplasty

METHODS We prospectively evaluated the outcomes of 2,000 patients undergoing percutaneous transluminal coronary angioplasty (PTCA). According to a randomized, double-blind protocol, they received either iomeprol (nonionic; n 5 1,001) or ioxaglate (ionic; n 5 999). Intracoronary thrombus before PTCA was found more often in the iomeprol group (4.2% vs 2.7%, p 5 0.04). No other significant differe...

Contrast nephropathy: isosmolar and low-osmolar contrast media.

1. Hurst RT, Askew JW, Reuss CS, et al. Transient midventricular ballooning syndrome: a new variant. J Am Coll Cardiol 2006;48: 579 – 83. 2. Sharkey SW, Lesser JR, Zenovich AG, et al. Acute and reversible cardiomyopathy provoked by stress in women from the United States. Circulation 2005;111:472–9. 3. Abdulla I, Kay S, Mussap C, et al. Apical sparing in tako-tsubo cardiomyopathy. Intern Med J 2...

Oxidant stress due to non ionic low osmolar contrast medium in rat kidney.

BACKGROUND & OBJECTIVES Contrast media may cause contrast-induced nephropathy (CIN) in risk group. This study was taken up to establish possible effects of non ionic low osmolar contrast medium administration on oxidant/antioxidant status and nitric oxide (NO) levels in rat kidney tissues. METHODS Fourteen female, 14 wk old Wistar-albino rats were divided into 2 groups of 7 rats each (control...